AF10 (ALL1 fused gene from chromosome 10)
نویسندگان
چکیده
منابع مشابه
Diversity of chromosome numbers and meiotic studies in genus Anchusa (Boraginaceae) from Iran (10 Nov 2015)
The present study reports the chromosome number and meiotic behaviour of 14 populationsbelonging to four taxa of Anchusa subgenus Buglossum Gusul. from Iran. All populationsshowed the chromosome number 2n= 4x= 32. It is the first meiotic study for A. subg.Buglossum. We discuss some habit form and evolutionary aspect in the light of cytogeneticdata. The origin of polyploidy (auto-allopolyploidy)...
متن کاملALL1 gene alterations in acute leukemia: biological and clinical aspects.
BACKGROUND AND OBJECTIVE The ALL1 gene, also referred to as MLL, HRX or Htrx1, is interrupted in the vast majority of translocations involving the chromosome band 11q23. Alterations in this gene are reported in approximately 5-10% of acute leukemias (AL) and characterize different leukemic subtypes such as infant (< 12 months of age) AL, topoisomerase II inhibitors-related (TR) AL and a small s...
متن کاملThe AF10 leucine zipper is required for leukemic transformation of myeloid progenitors by MLL-AF10.
The t(10;11)(p12;q23) chromosomal translocation in human acute myeloid leukemia results in the fusion of the MLL and AF10 genes. The latter codes for a novel leucine zipper protein, one of many MLL fusion partners of unknown function. In this report, we demonstrate that retroviral-mediated transduction of an MLL-AF10 complementary DNA into primary murine myeloid progenitors enhanced their clono...
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Changes in chromosome number impair fitness by disrupting the balance of gene expression. Here we analyze mechanisms to compensate for changes in gene dose that accompanied the evolution of sex chromosomes from autosomes. Using single-copy transgenes integrated throughout the Caenorhabditis elegans genome, we show that expression of all X-linked transgenes is balanced between XX hermaphrodites ...
متن کاملdiversity of chromosome numbers and meiotic studies in genus anchusa (boraginaceae) from iran (10 nov 2015)
the present study reports the chromosome number and meiotic behaviour of 14 populationsbelonging to four taxa of anchusa subgenus buglossum gusul. from iran. all populationsshowed the chromosome number 2n= 4x= 32. it is the first meiotic study for a. subg.buglossum. we discuss some habit form and evolutionary aspect in the light of cytogeneticdata. the origin of polyploidy (auto-allopolyploidy)...
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ژورنال
عنوان ژورنال: Atlas of Genetics and Cytogenetics in Oncology and Haematology
سال: 2010
ISSN: 1768-3262
DOI: 10.4267/2042/32046